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Etizolam (also known by the brand names Etilaam, Etizest) is in the class of thienodiazepines, related to benzodiazepines. It works by binding to GABA receptors in the brain.

Etizolam is not commonly prescribed in France. It is sold online as research chemicals and is commonly used as a substitute for pharmaceutical benzodiazepines such as alprazolam (Xanax) or diazepam (Valium).

Etizolam is classified as a psychotropic substance

Etizolam first appeared on the online research chemicals market in 2011. Since then, its popularity has grown steadily. This is likely due to both its low cost, its abundance, as well as its slightly euphoric effects.

Etizolam differs from most other research chemicals in that it is approved and actively prescribed as a medical treatment for anxiety in many countries, usually under brand names such as Etilaam and Etizest.

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Medical papers documenting its use in the treatment of anxiety have been documented as far back as the 1990s.

Etizolam is commonly found in the form of granules, tablets, blotter or as a pure white powder.

" ...if I may say so: the medium, whether it be blotting paper or an aggregate of excipients (tablet), does not create the danger.

I would go so far as to say that powder blenders/blenders to make tablets or capsules are less reliable than diluting in pure alcohol.

Then given the size of a square of blotter, and the volume of saturated alcohol necessary for 1 or 2mg of etizolam, we do not distribute "a drop" poof like that and basta: it would overflow the paper or spread beyond by capillarity. That's why we use a micro-pipette, and if you want to do things right, you deposit only a fraction of volume (expressed in micro-milliliter µml), then you wait for evaporation, then you start again, and so on several times until you reach the desired concentration on your blotter.

Etizolam can be consumed by vaping it: mixed with propylene glycol, with an electronic cigarette.

" Etizolam dissolves perfectly in PG and it is possible to add aroma and VG (I tried up to 10% VG), to have a "ready to drink" C-liquid.

It is important to leave a maturation time of at least 48 hours by shaking and degassing (opening the bottle, so that the solution is as homogeneous as possible (up to 1/2 week depending on the aromas, but more to do with the homogeneity).

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" My biggest concern with etizolam in e-liquid form is that it's particularly easy to black out.

I tend to want to pull the extra hit and... I don't remember everything the next day (not to mention that I bump into a lot of furniture and I'm very "dizzy").

I gave up this ROA, I can't manage the craving "which makes me want to go further".

Without any mixture with another psychotropic product, huh!!!

For Etizolam, I would make B-liquid (Benzo-liquid) dosed at 1 mg/ml, and I would take 2 ml tanks to consume.

This allows the user to know precisely the number of mg he has consumed. 1 tank = 1 tablet of 1 mg.

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Etizolam is often used for cathinone runs, with RC shops selling both.

" Basically here is how my descents take place depending on whether or not I have etizolam in my possession.

Without Etizolam: I go home full of prod, full of 3-MMC or my jaws still clenched under the effect of MD. I lay on my couch, I put on a movie and I start rolling farts. I can go up to 5 or 6 spliffs before I feel tired enough to hope to sleep. When I wake up, my head has exploded and I still feel all the products from the day before in my body.

With Etizolam: I go home and depending on the quantity of prods that I have swallowed, I send myself one or two pills, either 1 or 2mg of etizolam. Then I roll 1 or 2 spliffs. An hour later, I feel completely cocooned, I go to bed, I sleep 10 or 12 hours and I wake up spruce up, my brain rested.

Etizolam can cause severe blackouts, especially if taken in large doses.

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" Now the serious stuff. As the average dose is 1 mg, dosing is difficult. So I started by mixing about 20 mg in a 0.5 liter bottle.

I drink a few sips and everything goes well. I feel good but nothing special. However!!! In the middle of the night my girlfriend finds me walking around the apartment, like a sleepwalker. I even wanted to go to a festival to join friends (I was either delirious or dreaming). The worrying thing is that it lasted a good two hours and I don't remember it at all. My girlfriend ended up forcing me to go to bed and suddenly go to sleep (she told me everything) The next day I don't even know what time I got up and I went to class. But I had no memory of it the next day.

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A research chemical substance , or chemical product (sometimes called a pure substance ), is any sample of matter of defined chemical composition and exhibiting characteristic properties ( color , odor , density , melting point , etc. ), regardless of its origin.

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It is not always easy to give a precise definition of a chemical substance.

In general, this concept refers to a product manufactured ( synthesized ) by humans (not existing in nature or copying molecules existing in nature).

For the standardized administrative vocabulary of France and the European Union :

“chemical substances” designate “chemical elements and their compounds as they occur in their natural state or as they are obtained by any production process” 1 ;

the word “preparation” designates “mixtures or solutions composed of two or more substances

Number of different chemicals, and tonnages produced

The quantity of these products has greatly increased since the industrial revolution .

The number of different chemicals identified exceeded sixty-five million in 2009 (compared to eighteen million in 2002).

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It is estimated that approximately eleven thousand new substances were created per day from 2002 to 2009 2 . The CAS database counted 47,372,533 chemicals atJune 5, 20092 (including 34,961,413 products marketed 2 ).

More than 85,000 chemical substances are commercially available , and seven new substances are introduced into commerce every day 3 .

The annual global production of chemicals has also increased rapidly, from around one million tonnes per year around 1930 2 to over three hundred million tonnes in 2009 2 , largely synthesized from fossil hydrocarbons.

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Many of these products have been widely distributed in the environment where they degrade and/or circulate, via water and air , from where they end up in soils and sediments .

They form in the environment or in the organisms that ingest them by-products , metabolites , residues that can combine with other products (producing possible synergies (chemical, biochemical, etc. ).

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They are in particular found in water (including rainwater , mist and dew, for pesticides for example, but also in surface water , groundwater and drinking water for endocrine disruptors for example). Some of these products can be highly bioconcentrated in the food chain and then found in certain foods (meat, fish, flesh of filter feeding animals in particular).

Some are active at low or even very low doses, and are considered anthropogenic micropollutants of concern posing new challenges for environmental assessment 2

These are self-checks and checks carried out by the competent authorities, accompanied by possible sanctions provided for by law.

Given the number of products synthesized, placed on the market or used, the number of controls may seem modest.

For example, a little "more than 7,500 checks were carried out in 2010" at importers, manufacturers, those responsible for the first marketing, distributors and users of chemical products, often by "the labor inspectorate, the inspectors of classified installations, competition, consumer and fraud prevention officers, customs officers and inspectors from the French agency for the safety of health products, etc” 14 .

About 50% of these checks concerned compliance with the REACH regulation.

In France, increasing the frequency and quality of checks on chemical products was a request from the Grenelle Environment Forum as well as from the second National Environmental Health Plan and the Occupational Health Plan.

The legislator has provided for sanctions whose dissuasive nature for large groups is under debate, ranging from the administrative fine (still non-existent in 2012 in the field of installations classified for the protection of the environment ), to the consignment of sums and bans on the manufacture or export of chemicals.

The public prosecutor 's office must be notified of the checks carried out, without prejudice to the special rules applicable to labor inspection 14.

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The problems most frequently noted by the inspectors in 2010 were non-compliance with the safety data sheet for products classified as dangerous (which must comply with Article 31 and Annex II of Regulation (EC ) No 1907/2006), defects in labeling or instructions for biocidal products. In 2010, out of more than 7,500 checks, approximately 2% of findings (including those showing prohibited use of chemicals) were followed by administrative and criminal penalties

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